Flexible in vivo PK study designs



 Routes of Administration                                                             
  • Intravenous, Oral
  • Subcutanous, intaperitoneal, intramuscular,intradermal, topical
  • Intranasal, intratracheal
  • Intracolonic
Sampling Methods  
  • Serial sampling

   Tail-vein,saphenous vein 

  • Cathether(jugular,femoral)
  • Heart puncture (terminal)
 Sample types
  • Whole blood,plasma,serum
  • Tissues/organs
  • Excreta (urine,feces)
  • Cerebrospinal fluid (rat)
  Type of studies 
  •  Rapid screening studies to access exposure
  •  PK studies to estimate

    disposition kinetics and bioavailability

    dose proportionality

    routes to excretion (metabolic cages)

  •  Customized studies (CSF sampling,intestinal loops)
  •  Single and repeated dosing

 For further details on the ADME/PK services available at Fidelta, please follow the indicated links or contact us.