Phone: +385 1 8886300

Email: fidelta@glpg.com

Microbiology

Fidelta’s microbiology group is working with bacteria, fungi and viruses in laboratories certified for class 2 risk pathogens.
Our strain collection currently contains more than 1900 bacterial and 800 fungal strains with different resistance mechanisms against various antibiotic classes. Strains are phenotypically and genotypically characterized. We have established relationships with clinical centres that ensure access to recent and clinically relevant Gram-positive and Gram-negative pathogens.

We offer:
  • Compound profiling
    • Antimicrobial activity (MIC, MIC50, MIC90 and MBC) compliant with CLSI guidelines (microdilution, agar dilution and disc-diffusion)
    • Synergy testing of drug combinations (FIC index determination)
    • Time-kill studies
    • Single and multi-step resistance development propensity
    • PK/PD modelling
    • Mechanism of action determination
  • Biofilm studies
    • Biofilm formation/eradication using MBEC Assay (Calgary biofilm device)
    • Virulence factors determination
    • Host-pathogen interactions
  • Tailor-made assays for non-conventional compounds/agents or with clinical isolates provided by clients can also be developed

Data sheets

PHARMACOLOGY VIDEO

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