Phone: +385 1 8886300

Email: fidelta@glpg.com

Biochemistry

Fidelta’s biochemistry group has experience with a broad range of target classes including G-protein coupled receptors (GPCRs), nuclear receptors, ion channels, epigenetic targets, transporters, kinases, peptidases, hydrolases and other enzymes, etc.

We provide:
  • Development of new biochemical assays needed for compound profiling
  • Various readout options
    • Absorbance
    • Fluorescence (e.g. timed resolved fluorescence TRF, fluorescence resonance energy transfer FRET (DELFIA, LANCE), fluorescence polarization)
    • Luminescence (including alphaLISA)
    • Radioactivity
  • Data about efficacy, selectivity and establishment of structure activity relationship to aid further medicinal chemistry optimization
  • Analysis of signaling pathways by measuring the amount and/or posttranslational modifications of various signalling molecules by western blotting
  • Key equipment includes
    • Multifunctional plate readers (EnVision 2104, EnVision 2100, Tecan Infinite, LS55 Perkin Elmer)
    • Imager (Storm, Molecular Dynamics)
    • Scintillation counters (TopCount and TriCarb, Perkin Elmer)
    • Liquid handling units (Janus, Perkin Elmer)
    • Nanoliter dispensing units (Mosquito, TTP Labtech)
    • Multidrops (Combi nL, Thermo Scientific).

Data sheets

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