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Mouse Sepsis Model Induced by IP Infection with K. Pneumoniae, P. Aeruginosa and S. Aureus

Acute septicaemia in mice is the basic and most frequently used model in early evaluation of novel therapies. Mouse septicaemia model is simple to use as regards techniques of infection, treatment and data evaluation as well as economical concerning amounts of substances and duration.

Basic study design include single treatment prior to infection and monitoring of mortality up to 48-72h. Efficacy of the test compound is presented as survival rates.

Species, strain, sex:
mouse, BALB/c, male
mouse, C57Bl/6N, male
Number of animals /group:
n=10
Pharmacological control:
Meropenem
Tobramycin                  
Amoxicillin+Clavulanic acid
Strain:
K. pneumoniae  1470
(ESBL producing clinical isolate)
P. aeruginosa ATCC 27853
S. aureus  ATCC 29213
Treatment mode:
prophylactic/therapeutic
Duration of dosing:   
single/multiple dosing
Main read-outs:
Survival rates
Facultative read-outs:
CFUs in blood and kidneys

 

Models of infection with other bacteria of interest can be developed on request, using bacterial isolates from our collection or provided by the Client.

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