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Mouse Anti-CD3 Induced Inflammation

The CD3 complex is a part of TCR receptor of T-cells. Anti-CD3 antibodies stimulate T-cell functional responses  identical to antigen induced responses and stimulate all T-cells in a mixed population, regardless of antigen specificity.

Activity of the test compound is evaluated on the basis of inhibition of IL-2 production 90 – 180 min after  intravenous anti-CD3  administration.

Species, strain, sex:
mouse, BALB/c, female
Number of animals /group:
n=10
Pharmacological control:
Cyclosporine A
Routes of administration:
upon request
Treatment mode:
 
mechanistic
Duration of dosing:   
upon request

Read-out:
IL-2 concentration in serum

 
 
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