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KLH Induced Delayed Type Hypersensitivity in the Rat

Animals are immunized with keyhole limpet hemocyanin to induce a hypersensitivity reaction. This leads to elevated tissue concentrations of IL-1b (Th1) and IL-4 (Th2) cytokines.

Ear or punch biopsy weight is measured  at the end of the study. Ears and other selected tissues are collected to be subsequently analyzed or sent to the client, as requested.

Species, strain, sex:
rat, Lewis, male
Number of animals /group:
n=8
Pharmacological control:
cyclosporine A, dexamethasone,
tacrolimus
Routes of administration:
upon request
Treatment mode:
prophylactic, therapeutic
Duration of dosing:   
upon request
Main read-outs:
ear swelling
caliper measurement
weight
Facultative read-outs:
cytokines in tissue homogenates
histopathology

Inflammation in ear

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