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Acute COPD exacerbation in mice with Influenza A virus (Puerto Rico/8/1934(H1N1))

BALB/c mice are exposed to tobacco smoke for 3 days and intranasally inoculated with PR8 (H1N1) at 24h following the last tobacco smoke exposure

Read-outs:

  • total and differential cell count in BALF
  • viral load in lung tissue
  • concentration of cytokines in lung tissue

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