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Chronic DSS Induced Colitis in Mice

Inflammatory bowel diseases (IBD), Crohn’s disease and ulcerative colitis are disorders characterized by a chronic relapsing-remitting inflammation of the gastrointestinal tract.  To induce a colitis, DSS is administered in drinking water for 18 days.

Activity of test compounds is evaluated by daily monitoring of body weight and rectal bleeding as well as colon stretching at the end of the study. Colon tissue and other selected tissues can be collected for subsequent analyses (facultative read-outs).

Species, strain, sex:
mouse, C57Bl/6, male
Number of animals /group:
n=15
Pharmacological control:
Cyclosporine A, Sulphasalazine
Routes of administration:
upon request
Treatment mode:
therapeutic

  
 
Main read-outs:
- colon stretching
- body weight
- rectal bleeding
Facultative read-outs:
- haematology
- histopathology
- inflammatory mediators in colon tissue homogenates

Effect of CsA on colon streching in
mouse DSS induced colitis

 

Effect of CsA on MPO concentration in
colon tissue in mouse DSS induced colitis



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