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Bleomycin Induced Pulmonary fibrosis in mice

Species, strain, sex:
mouse, C57Bl/6, male
Pharmacological control:
Pirfenidone, Nintedanib, SB525334
Routes of administration:
upon request
Treatment mode:
prophylactic/therapeutic
Duration:
14/21 days
 
Basic read-outs: Facultative read outs:
  • body weight
  • lung function measurements
  • lung weight
  • cell counts in BALF
  • histopathology (Matsuse modification of Ashcroft score)
  • IHC/IF
 
  • gene expression in lung tissue

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