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Inflammation
Respiratory diseases
In vivo models of respiratory inflammation
Asthma (mice)
- Ovalbumin
- HDM
- HDM/CFA severe neutrophilic asthma
COPD (mice and rats)
- Tobacco smoke induced acute and sub-acute pulmonary inflammation
- LPS induced pulmonary neutrophilia
Viral exacerbations of asthma and COPD (mice)
- Rhinovirus (RV-1B)
- Influenza (Puerto Rico/8/1934(H1N1))
Respiratory syncytial virus (RSV/A2)
Read-outs:
- total and differential cell count in BALF
- lung function (resistance and compliance)
- histopathology
- inflammatory mediators in BALF
- immunohistochemistry
Gastrointestinal disorders
In vivo models of GI disorders
- Functional models (mice and rats)
- Gastric emptying
- Intestinal secretion
- GI transit
- Closed intestinal loops
- Intestinal growth
- Models of inflammatory bowel disease (IBD)
- DSS (mice, rats)
- TNBS (rats)
- Oxazolone (rats)
- CD4+CD25-CD62L+ T cell transfer chronic colitis in SCID mice
- Read outs:
- Colon length (streching)
- histopathology
- disease activity score (DAI)
- inflammatory mediators in colon tissue
Rheumatoid arthritis
In vivo models of RA
- Collagen type-II (CIA) (mice, rats)
Read outs:
- Clinical score
- Paw swelling
- Haematology
- Histopathology
- Immunohistochemistry
- Serum biomarkers
- inflammatory mediators
- Screening model: LPS induced bone erosion (mice)
Read outs:Serum markers of bone erosion
Skin inflammation
In vivo models of skin inflammation
- Imiquimod induced psoriasis (mice)
- Delayed type hypersensitivity (DTH)
- Oxazolone (acute/chronic) (mice)
- KLH (mice and rats)
- Wound healing (mice and rats)