In vivo models of infection
The models are covering bacterial and viral infections, with localised and systemic infection sites. Screening models such as bacterial sepsis or thigh infections induced by Gram positive and Gram negative ATCC strains or clinical isolates can be effectively integrated with more complex disease models including respiratory, urinary and skin infections. Viral models include respiratory syncytial virus (RSV) and influenza A (H1N1) induced respiratory tract infections. A variety of administration routes and dosing regimens are available for compound testing. For all infection models developed and validated in mice, rats and rabbits, a wide range of read-outs can be selected and flexibly combined: CFU counts (or viral titers), survival rates, inflammatory mediators, cell counts in bronchoalveolar lavage fluid as well as histopathological assessment.