Phone: +385 1 8886300

Email: fidelta@glpg.com

General info

Synopsis

The objective of this symposium is to promote scientific interaction between scientists with a shared interest in the field of Macrocycles. This area is responsible for a growing number of therapeutic approaches and development candidates, all of which go 'beyond the rule-of –five'. As a researcher in this field, come along to hear about the latest advances and also share in some of the secrets of discovering therapeutic agents which go beyond Lipinski's rules.

Programme
Monday 17th October

09:00 Registration
10:00 Opening remarks
10:15 Introduction to the area
  Gordon Saxty, Fidelta
10:30 Plenary: Cyclic peptides - what we know and don't know
  Michael Shapiro, Independent Scientist
11:30 A game changing new antibiotic? The discovery of Teixobactin
  Vicky Steadman, Selcia
12:15 Evolution of cyclic peptide inhibitors of the Gag-TSG101 protein-protein interaction involved in HIV budding
  Katherine Lennard, University of Southampton
12;30 Lunch and poster session
14:00 Successive ring expansion: from 'ball-in-a-cup' to complex macrocycles with medicinal applications
  Will Unsworth, University of York
14:45 New synthetic anti tuberculosis cyclohexylgriselimycin (CGM), more than 50 years after the isolation of the natural griselimycin
  Evelyne Fontaine, Sanofi
15:30 Refreshments
16:00 Semi-peptidic macrocycles: applications to GPCR drug discovery and structure-permeability relationships
  Eric Marsault, L'Université de Sherbrooke
16:45 Stabilised peptides in drug discovery
  Andrew Mason, GlaxoSmithKline
17:30 Close
19:00 Conference meal for all delegates

Tuesday 18th October

09:00 New opportunities for macrolide antibiotics
  Biljana Arsic, University of Manchester
09:45 Total synthesis of the potent GRP78 downregulatory anti-tumour macrolide, (+)-Prunustatin A, and the immunosuppressant (+)-SW-163A
  Karl Hale, Queen's University Belfast
10:30 Refreshments
11:00 GLPG1492, a semi-synthetic natural product demonstrating remarkable antibacterial potency via an unexploited mode of action
  Ann de Blieck, Galapagos
11:45 Natural-product derived novel chemical space - an underexplored opportunity in drug discovery
  Bart Decorte, Janssen Pharmaceutical Companies of Johnson & Johnson (retired) and Kodib, LLC
12:30 Closing remarks
12:45 Light lunch and depart

Call for Papers

Are you a young researcher (postgraduate student, postdoctoral fellow or young academic, appointed since 2011)? Are you working in the synthesis, biological activity or medicinal chemistry of macrocycles?

If yes, then this is your chance to present your work at a major international symposium. The organising committee are looking for some young researchers to give a short, oral presentation on their research at this symposium. Deadlines are:

  • 11th August (call for posters and short talks)

Please download an abstract template here.

Sponsors

We were grateful to the endorsement of the Croatian Academy of Sciences and Arts (HAZU), the Croatian Chemical Society (HKD) for their support of this symposium, and to our principal sponsor, Fidelta.  Additional sponsors are sought.

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Organising Committee

Dr Dave Alker, RSC-BMCS

Dr Gordon Saxty, Fidelta (chairman)

Professor Vitomir Šunjić, Croatian Chemical Society

Secretariat Contact

Maggi Churchouse Events, 3 East Barn, Market Weston Road, Thelnetham, Diss IP22 1JJ, UK

E-mail Maggi Churchouse to register an interest in this symposium.

Telephone: +44 (0)1359 221004


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